https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology offers a range of options to lead to biology. Below I'll existing illustrations where by nanofabrication – a chance to make confined buildings with Proportions at will – is utilized to examine the biophysics of single molecules and cells. I will present some illustrations from our lab:
Our group studies bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells that could autonomously divide. Our major curiosity lies in mobile division, chromatin framework, and spatial Handle.
Multicolor imaging from the bacterial nucleoid and mobile division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand moments in the reliable condition nanopore
2010, designed a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation by means of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
Our research ranges in the biophysics of DNA to synthetic cells and beyond. Please take a look down below within the spectrum of our present-day jobs.
Many associated developments followed, exactly where our group set up distinct transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest proof-of-theory electronic circuits.
Illustration (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in grey, the rim of the pore is highlighted in purple, and a 3D rendering with the motion with the DNA rod is displayed.
‘Sure, I have an understanding of folks were being shocked at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to admit that it experienced become a little bit bored, I didn’t master Significantly anymore. The field went a lot more into the applying side, how you might combine nanotubes into electronic circuits.
At the moment, we also recognized that it should be feasible to make use of just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and applied the underlying silicon substrate like a gate electrode, setting up the basic a few-terminal structure of a area-effect transistor (Fig.
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Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes from the nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, particularly SMC ceesdekker.net motor protein; and (iii) building a dwelling artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member on the KNAW and fellow for the APS along with the IOP.
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2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes